Abnormal regulation of vitamin A can lead to schizophrenia

Shanghai Jiaotong University, Bio-X Center was established in 2005 by NHGG (Neuropsychiatric and Human Genetics Group, Neuropsychiatric and human genetics research), and established in 2000, Bio-X Life Science Research Base through the re-formed. Recent from the Bio-X Center researchers Prog Neuropsychopharmacol Biol Psychiatry journal published an article revealing the Han population of retinoic aldehyde dehydrogenase 1A2 (ALDH1A2) gene and schizophrenia, the positive association.

 

Disease mechanisms in schizophrenia research have researchers put forward the "abnormal regulation of vitamin A may be an important factor in occurrence of schizophrenia" hypothesis. Affect the human body, active form of vitamin A - the level of retinoic acid synthesis mainly in the rate-limiting enzyme retinaldehyde dehydrogenase ALDH1 and the hydroxylation of retinoic acid degradation of CYP26. These enzymes and vitamin A transport protein in the combined effect of the play biological functions. Of vitamin A pathway in the important genes associated with schizophrenia research, will be "abnormal regulation of vitamin A may be an important factor in occurrence of schizophrenia" hypothesis provides important information.

 

In this paper, researchers at the Han people in 617 pairs of ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1, CYP26C1 and TTR (thyroxine-transferase, a transporter protein, vitamin A) This seven genes and schizophrenia Association analysis of the relationship between the system, from the perspective of genetics abnormal regulation of vitamin A is associated with schizophrenia. The results showed that these gene locus allele and genotype associated with schizophrenia were not shown, while the ALDH1A2 gene haplotype rs4646642-rs4646580 showed significant association with disease (p = 0.0055). The study is the first systematic metabolic pathway of vitamin A on the key genes and schizophrenia conducted by correlation analysis, the results for schizophrenia, the hypothesis of abnormal regulation of vitamin A reliable experimental support, and for a better understanding of the mechanism pointed out that the study of disease Direction